H2AJ

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity. [provided by RefSeq, Oct 2015]

Description

H2A.J histone

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins

Chromosome

12 (14774383 - 14778002)

Ensembl ID

ENSG00000246705  (ver. 103.38)

Orthologs

Mouse H2aj: ENSMUSG00000060032

UniProt

Q9BTM1

neXtProt

NX_Q9BTM1

Human splice variants
Mouse splice variants

Protein structure