Tissue expression
Cell line expression
Protein structure
CASP10
Caspase 10FLICE-2, MCH4
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Top validated antibodies |
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Proteintech Group | 14311-1-AP | 2 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
antibodies-online | ABIN393204 | 5 references | Monoclonal |
WB
EL
ICC
IHC |
|
Invitrogen Antibodies | 14311-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
|
||
GeneTex | GTX113148 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
NovoPro Bioscience Inc. | 108871 | Polyclonal |
WB
EL
ICC
IP
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider