PLAUR

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

Description

Plasminogen activator, urokinase receptor

Tissue specificity

Tissue enriched (bone marrow)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
CD markers
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (43646095 - 43670547)

Ensembl ID

ENSG00000011422  (ver. 103.38)

Orthologs

Mouse Plaur: ENSMUSG00000046223

UniProt

Q03405

neXtProt

NX_Q03405

Human splice variants
Mouse splice variants

Protein structure