CD6

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Description

CD6 molecule

Tissue specificity

Tissue enhanced (intestine, lymphoid tissue)

Predicted location

Membrane, Secreted to blood

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (60971680 - 61020377)

Ensembl ID

ENSG00000013725  (ver. 103.38)

Orthologs

Mouse Cd6: ENSMUSG00000024670

UniProt

P30203

neXtProt

NX_P30203

Human splice variants
Mouse splice variants

Protein structure