IKZF2

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Description

IKAROS family zinc finger 2

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Nucleoplasm, Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

2 (212999691 - 213152427)

Ensembl ID

ENSG00000030419  (ver. 103.38)

Orthologs

Mouse Ikzf2: ENSMUSG00000025997

UniProt

Q9UKS7

neXtProt

NX_Q9UKS7

Human splice variants
Mouse splice variants

Protein structure