Tissue expression
Cell line expression
Protein structure
SIRT6
Sirtuin 6This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Top validated antibodies |
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Novus Biologicals | ![]() |
13 references | Polyclonal |
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Proteintech Group | ![]() |
43 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
2 references | Polyclonal |
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antibodies-online | ![]() |
11 references | Polyclonal |
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St John's Laboratory | ![]() |
Monoclonal |
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