DYNLL1

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Description

Dynein light chain LC8-type 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (120469850 - 120498493)

Ensembl ID

ENSG00000088986  (ver. 103.38)

Orthologs

Mouse Dynll1: ENSMUSG00000009013

UniProt

P63167

neXtProt

NX_P63167

Human splice variants
Mouse splice variants

Protein structure