Tissue expression
Cell line expression
Protein structure
AGO1
Argonaute RISC component 1EIF2C1, hAGO1
This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]
Top validated antibodies |
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Proteintech Group | 19690-1-AP | 1 references | Polyclonal |
WB
EL
ICC
IHC |
|
LSBio | LS-C782018 | Polyclonal |
WB
IHC |
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Novus Biologicals | NB100-2817 | 3 references | Polyclonal |
WB
EL
IHC
|
|
Invitrogen Antibodies | PA5-78737 | Polyclonal |
WB
ICC
IHC
FC |
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NSJ Bioreagents | RQ7060 | Polyclonal |
WB
EL
ICC
FC |
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Supportive data in Antibodypedia
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider