Tissue expression
Cell line expression
Protein structure
TGFB2
Transforming growth factor beta 2This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Top validated antibodies |
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Proteintech Group | 19999-1-AP | 28 references | Polyclonal |
WB
EL
ICC
IHC |
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Invitrogen Antibodies | 710276 | 1 references | Polyclonal |
WB
FC
OA
|
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antibodies-online | ABIN2838086 | 2 references | Monoclonal |
WB
ICC
IHC
|
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R&D Systems | MAB612-100 | 3 references | Monoclonal |
WB
EL
IHC
|
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Novus Biologicals | AB-12-NA | 6 references | Polyclonal |
WB
BN |
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