Tissue expression
Cell line expression
Protein structure
LRRFIP2
LRR binding FLII interacting protein 2HUFI-2
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
Top validated antibodies |
|||||
GeneTex | GTX31429 | Polyclonal |
WB
EL
ICC
IHC |
||
Boster Biological Technology | A08734 | Polyclonal |
WB
EL
ICC
IHC |
||
antibodies-online | ABIN2448524 | Polyclonal |
WB
EL
ICC
IHC |
||
Novus Biologicals | 43620002 | 2 references | Polyclonal |
WB
EL |
|
LSBio | LS-C144340 | Polyclonal |
WB
EL
ICC
IHC |
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Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider