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Protein structure
SIRT1
Sirtuin 1SIR2L1
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Top validated antibodies |
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| LSBio |  LS-C746926 |
Polyclonal |
WB
ICC
IP
IHC
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| Proteintech Group | 13161-1-AP |
335 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | MA5-15677 |
2 references | Monoclonal |
WB
EL
ICC
IHC
FC
OA
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| Novus Biologicals | H00023411-M01 |
4 references | Monoclonal |
WB
EL
ICC
IHC
ChIP
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| GeneTex | GTX82793 |
1 references | Monoclonal |
WB
EL
ICC
IHC
FC
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