POLR2E

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Description

RNA polymerase II, I and III subunit E

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
RNA polymerase related proteins

Chromosome

19 (1086574 - 1095380)

Ensembl ID

ENSG00000099817  (ver. 103.38)

Orthologs

Mouse Polr2e: ENSMUSG00000004667

UniProt

P19388

neXtProt

NX_P19388

Human splice variants
Mouse splice variants

Protein structure