Tissue expression
Cell line expression
Protein structure
PPM1A
Protein phosphatase, Mg2+/Mn2+ dependent 1AMGC9201, PP2CA, PP2Calpha
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Invitrogen Antibodies | PA5-29275 | 2 references | Polyclonal |
WB
ICC
IHC
ChIP
OA
|
|
Cell Signaling Technology, Inc | 3549 | 1 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
|
antibodies-online | ABIN969556 | 2 references | Monoclonal |
WB
EL
FC
|
|
Novus Biologicals | H00005494-M03 | Monoclonal |
WB
EL
ICC
IHC
PLA
|
||
GeneTex | GTX109744 | 1 references | Polyclonal |
WB
ICC
IHC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider