ATG4A

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq, Mar 2016]

Description

Autophagy related 4A cysteine peptidase

Tissue specificity

Low tissue specificity

Subcell location

Actin filaments, Microtubules

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (108091668 - 108154671)

Ensembl ID

ENSG00000101844  (ver. 103.38)

Orthologs

-

UniProt

Q8WYN0

neXtProt

NX_Q8WYN0

Human splice variants

Protein structure