Tissue expression
Cell line expression
Protein structure
CTCF
CCCTC-binding factorCFAP108, FAP108
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Top validated antibodies |
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Invitrogen Antibodies | PA5-88115 | 1 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
OA |
|
Proteintech Group | 10915-1-AP | 3 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
Cell Signaling Technology, Inc | 3418 | 2 references | Monoclonal |
WB
ICC
IP
IHC
ChIP
|
|
Novus Biologicals | NB500-177 | 1 references | Polyclonal |
WB
IP
IHC
ChIP |
|
antibodies-online | ABIN2668282 | Polyclonal |
WB
ICC
IHC
FC
ChIP
|
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Supportive data in Antibodypedia
Data presented on provider website
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Recommended by provider