Tissue expression
Cell line expression
Protein structure
MAN2B1
Mannosidase alpha class 2B member 1LAMAN, MANB
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Top validated antibodies |
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Biorbyt | orb2208859 | Polyclonal |
WB
ICC
IP
IHC |
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antibodies-online | ABIN4332562 | Polyclonal |
IHC
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Novus Biologicals | H00004125-B01P | Polyclonal |
WB
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Abnova Corporation | H00004125-B01P | Polyclonal |
WB
|
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Atlas Antibodies | HPA041530 | Polyclonal |
IHC
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