TLE6

This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Description

TLE family member 6, subcortical maternal complex member

Tissue specificity

Tissue enhanced (thyroid gland)

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

19 (2977538 - 2995179)

Ensembl ID

ENSG00000104953  (ver. 103.38)

Orthologs

Mouse Tle6: ENSMUSG00000034758

UniProt

Q9H808

neXtProt

NX_Q9H808

Human splice variants
Mouse splice variants

Protein structure