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ATP6V0A4
ATPase H+ transporting V0 subunit a4a4, ATP6N1B, ATP6N2, RDRTA2, RTA1C, RTADR, Stv1, Vph1, VPP2
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| LSBio |  LS-B10794 |
Polyclonal |
WB
IHC
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| Proteintech Group | 21570-1-AP |
1 references | Polyclonal |
WB
EL
IHC
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| Invitrogen Antibodies | 21570-1-AP |
Polyclonal |
WB
IHC
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| antibodies-online | ABIN2840303 |
Polyclonal |
WB
FC
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| GeneTex | GTX110255 |
Polyclonal |
WB
ICC
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