Tissue expression
Cell line expression
Protein structure
MAPK8
Mitogen-activated protein kinase 8JNK, JNK1, PRKM8, SAPK1
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Top validated antibodies |
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Proteintech Group | 51151-1-AP | 104 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
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Invitrogen Antibodies | 44-690G | 16 references | Polyclonal |
WB
IHC
FC
OA |
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Novus Biologicals | H00005599-M11 | 1 references | Monoclonal |
WB
EL
ICC
BN
PLA
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Boster Biological Technology | MP02608 | 9 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
|
Cell Signaling Technology, Inc | 9255 | 7 references | Monoclonal |
WB
ICC
IP
FC |
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