RBBP5

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]

Description

RB binding protein 5, histone lysine methyltransferase complex subunit

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (205086142 - 205122015)

Ensembl ID

ENSG00000117222  (ver. 103.38)

Orthologs

Mouse Rbbp5: ENSMUSG00000026439

UniProt

Q15291

neXtProt

NX_Q15291

Human splice variants
Mouse splice variants

Protein structure