Tissue expression
Cell line expression
Protein structure
DR1
Down-regulator of transcription 1NC2-BETA, NC2B, NCB2
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Invitrogen Antibodies | PA5-117920 | Polyclonal |
WB
ICC
IP
IHC
OA
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NSJ Bioreagents | RQ5811 | Polyclonal |
WB
EL
ICC
IHC
FC
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Proteintech Group | 10406-1-AP | 2 references | Polyclonal |
WB
EL
IHC
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Boster Biological Technology | A02204-1 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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Atlas Antibodies | HPA055308 | Polyclonal |
WB
ICC
IHC
|
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