CA14

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]

Description

Carbonic anhydrase 14

Tissue specificity

Tissue enhanced (choroid plexus, retina, skeletal muscle, tongue)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (150257251 - 150265078)

Ensembl ID

ENSG00000118298  (ver. 103.38)

Orthologs

Mouse Car14: ENSMUSG00000038526

UniProt

Q9ULX7

neXtProt

NX_Q9ULX7

Human splice variants
Mouse splice variants

Protein structure