Tissue expression
Cell line expression
Protein structure
PSPC1
Paraspeckle component 1FLJ10955, PSP1
This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]
Top validated antibodies |
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Invitrogen Antibodies | PA5-118216 | Polyclonal |
WB
ICC
IP
IHC
OA
|
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NSJ Bioreagents | RQ8334 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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Proteintech Group | 16714-1-AP | 1 references | Polyclonal |
WB
EL
ICC
IP |
|
Atlas Antibodies | HPA038904 | Polyclonal |
WB
ICC
IHC
|
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Biorbyt | orb1743827 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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Supportive data in Antibodypedia
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Recommended by provider