RGS13

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]

Description

Regulator of G protein signaling 13

Tissue specificity

Tissue enriched (lymphoid tissue)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (192636138 - 192660311)

Ensembl ID

ENSG00000127074  (ver. 103.38)

Orthologs

Mouse Rgs13: ENSMUSG00000051079

UniProt

O14921

neXtProt

NX_O14921

Human splice variants
Mouse splice variants

Protein structure