FGFRL1

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Fibroblast growth factor receptor like 1

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Intracellular, Membrane

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Chromosome

4 (1009936 - 1026898)

Ensembl ID

ENSG00000127418  (ver. 103.38)

Orthologs

Mouse Fgfrl1: ENSMUSG00000008090

UniProt

Q8N441

neXtProt

NX_Q8N441

Human splice variants
Mouse splice variants

Protein structure