VPREB3

The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]

Description

V-set pre-B cell surrogate light chain 3

Tissue specificity

Tissue enhanced (epididymis, intestine, lymphoid tissue)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

22 (23752743 - 23754425)

Ensembl ID

ENSG00000128218  (ver. 103.38)

Orthologs

Mouse Vpreb3: ENSMUSG00000000903

UniProt

Q9UKI3

neXtProt

NX_Q9UKI3

Human splice variants
Mouse splice variants

Protein structure