DPP6

This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Description

Dipeptidyl peptidase like 6

Tissue specificity

Tissue enhanced (brain, endometrium)

Predicted location

Membrane

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

7 (153887097 - 154894285)

Ensembl ID

ENSG00000130226  (ver. 103.38)

Orthologs

Mouse Dpp6: ENSMUSG00000061576

UniProt

P42658

neXtProt

NX_P42658

Human splice variants
Mouse splice variants

Protein structure