AGAP3

This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]

Description

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (151085831 - 151144436)

Ensembl ID

ENSG00000133612  (ver. 103.38)

Orthologs

Mouse Agap3: ENSMUSG00000023353

UniProt

Q96P47

neXtProt

NX_Q96P47

Human splice variants
Mouse splice variants

Protein structure