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Protein structure
DSC2
Desmocollin 2CDHF2, DSC3
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Top validated antibodies |
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| Proteintech Group |  13876-1-AP |
6 references | Polyclonal |
WB
EL
ICC
IHC
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| NSJ Bioreagents | V3268 |
14 references | Monoclonal |
WB
ICC
IHC
FC
OA
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| Novus Biologicals | 22470002 |
2 references | Polyclonal |
WB
EL
IHC
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| Atlas Antibodies | HPA012615 |
1 references | Polyclonal |
IHC
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| Biorbyt | orb1252307 |
Monoclonal |
WB
ICC
IHC
FC
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