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MDM2
MDM2 proto-oncogeneHDM2, MGC5370
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Top validated antibodies |
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| GeneTex |  GTX100531 |
4 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
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| Invitrogen Antibodies | MA1-113 |
20 references | Monoclonal |
WB
ICC
IP
IHC
OA
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| antibodies-online | ABIN2845752 |
2 references | Polyclonal |
WB
ICC
IHC
FC
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| Novus Biologicals | NBP2-17247 |
1 references | Polyclonal |
WB
IP
IHC
ChIP
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| Proteintech Group | 19058-1-AP |
42 references | Polyclonal |
WB
EL
FC
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