DOCK10

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

Description

Dedicator of cytokinesis 10

Tissue specificity

Tissue enhanced (brain, lymphoid tissue)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (224765090 - 225042468)

Ensembl ID

ENSG00000135905  (ver. 103.38)

Orthologs

Mouse Dock10: ENSMUSG00000038608

UniProt

Q96BY6

neXtProt

NX_Q96BY6

Human splice variants
Mouse splice variants

Protein structure