SCN7A

This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]

Description

Sodium voltage-gated channel alpha subunit 7

Tissue specificity

Tissue enhanced (ovary)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (166403573 - 166611482)

Ensembl ID

ENSG00000136546  (ver. 103.38)

Orthologs

Mouse Scn7a: ENSMUSG00000034810

UniProt

Q01118

neXtProt

NX_Q01118

Human splice variants
Mouse splice variants

Protein structure