Tissue expression
Cell line expression
Protein structure
TPMT
Thiopurine S-methyltransferaseThis gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
Top validated antibodies |
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Novus Biologicals | ![]() |
2 references | Monoclonal |
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Proteintech Group | ![]() |
1 references | Polyclonal |
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Abnova Corporation | ![]() |
2 references | Monoclonal |
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antibodies-online | ![]() |
Monoclonal |
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LSBio | ![]() |
Polyclonal |
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