DNAJC13

This gene encodes a member of the Dnaj protein family whose members act as co-chaperones of a partner heat-shock protein by binding to the latter and stimulating ATP hydrolysis. The encoded protein associates with the heat-shock protein Hsc70 and plays a role in clathrin-mediated endocytosis. It may also be involved in post-endocytic transport mechanisms via its associations with other proteins, including the sorting nexin SNX1. Mutations in this gene are associated with Parkinson's disease. [provided by RefSeq, Jun 2016]

Description

DnaJ heat shock protein family (Hsp40) member C13

Tissue specificity

Low tissue specificity

Subcell location

Vesicles, Cytosol

Predicted location

Membrane

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (132417502 - 132539032)

Ensembl ID

ENSG00000138246  (ver. 103.38)

Orthologs

Mouse Dnajc13: ENSMUSG00000032560

UniProt

O75165

neXtProt

NX_O75165

Human splice variants
Mouse splice variants

Protein structure