SEMA7A

This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Description

Semaphorin 7A (John Milton Hagen blood group)

Tissue specificity

Tissue enhanced (lymphoid tissue, retina)

Subcell location

Vesicles

Predicted location

Membrane

Protein family

Blood group antigen proteins
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (74409289 - 74433958)

Ensembl ID

ENSG00000138623  (ver. 103.38)

Orthologs

Mouse Sema7a: ENSMUSG00000038264

UniProt

O75326

neXtProt

NX_O75326

Human splice variants
Mouse splice variants

Protein structure