FOXN4

Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]). [supplied by OMIM, Mar 2008]

Description

Forkhead box N4

Tissue specificity

Tissue enriched (testis)

Subcell location

Nucleoplasm, Mitochondria, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

12 (109277978 - 109309284)

Ensembl ID

ENSG00000139445  (ver. 103.38)

Orthologs

Mouse Foxn4: ENSMUSG00000042002

UniProt

Q96NZ1

neXtProt

NX_Q96NZ1

Human splice variants
Mouse splice variants

Protein structure