TLE3

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Description

TLE family member 3, transcriptional corepressor

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (70047790 - 70098176)

Ensembl ID

ENSG00000140332  (ver. 103.38)

Orthologs

Mouse Tle3: ENSMUSG00000032280

UniProt

Q04726

neXtProt

NX_Q04726

Human splice variants
Mouse splice variants

Protein structure