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Protein structure
BCL10
BCL10 immune signaling adaptorc-E10, CARMEN, CIPER, CLAP, mE10
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Top validated antibodies |
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| antibodies-online |  ABIN1724629 |
3 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| Novus Biologicals | NBP1-51524 |
1 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| GeneTex | GTX109159 |
1 references | Polyclonal |
WB
IP
IHC
ChIP
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| Proteintech Group | 50180-1-AP |
2 references | Polyclonal |
WB
EL
IHC
FC
|
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| OriGene | AM06073PU-N |
Monoclonal |
WB
EL
ICC
IHC
FC
|
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