Tissue expression
Cell line expression
Protein structure
NECTIN4
Nectin cell adhesion molecule 4LNIR, nectin-4, PRR4, PVRL4
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined. [provided by RefSeq, Jan 2011]
Top validated antibodies |
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Proteintech Group | 21903-1-AP | 2 references | Polyclonal |
WB
EL
ICC
FC |
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Novus Biologicals | AF2659 | 10 references | Polyclonal |
WB
IHC
FC
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R&D Systems | AF2659 | 10 references | Polyclonal |
WB
IHC
FC
|
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Atlas Antibodies | HPA010775 | Polyclonal |
WB
ICC
IHC
|
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Invitrogen Antibodies | 21903-1-AP | Polyclonal |
WB
ICC
IHC
FC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider