Tissue expression
Cell line expression
Protein structure
PTPN7
Protein tyrosine phosphatase non-receptor type 7HEPTP, LC-PTP
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]
Top validated antibodies |
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Proteintech Group | ![]() |
3 references | Polyclonal |
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antibodies-online | ![]() |
4 references | Polyclonal |
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Abnova Corporation | ![]() |
3 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
Monoclonal |
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Biorbyt | ![]() |
Polyclonal |
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