Tissue expression
Cell line expression
Protein structure
DUSP11
Dual specificity phosphatase 11PIR1
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
Top validated antibodies |
|||||
Proteintech Group | 10204-2-AP | 8 references | Polyclonal |
WB
EL
ICC
|
|
NovoPro Bioscience Inc. | 110115 | Polyclonal |
WB
EL
ICC
|
||
FineTest Biotech | FNab02563 | Polyclonal |
WB
EL
ICC
|
||
Biorbyt | orb183221 | Polyclonal |
EL
ICC
IHC
|
||
Invitrogen Antibodies | 10204-2-AP | Polyclonal |
WB
ICC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider