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PAK1
P21 (RAC1) activated kinase 1This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| Invitrogen Antibodies |  71-9300 |
9 references | Polyclonal |
WB
EL
ICC
IP
FC
OA
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| Novus Biologicals | H00005058-M02 |
1 references | Monoclonal |
WB
EL
ICC
IP
IHC
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| Abnova Corporation | H00005058-M02 |
1 references | Monoclonal |
WB
EL
ICC
IP
IHC
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| Proteintech Group | 21401-1-AP |
9 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| antibodies-online | ABIN562102 |
1 references | Monoclonal |
WB
EL
ICC
IP
IHC
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