SORCS3

This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014]

Description

Sortilin related VPS10 domain containing receptor 3

Tissue specificity

Group enriched (adrenal gland, brain)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Chromosome

10 (104641290 - 105265242)

Ensembl ID

ENSG00000156395  (ver. 103.38)

Orthologs

Mouse Sorcs3: ENSMUSG00000063434

UniProt

Q9UPU3

neXtProt

NX_Q9UPU3

Human splice variants
Mouse splice variants

Protein structure