Tissue expression
Cell line expression
Protein structure
FBXW5
F-box and WD repeat domain containing 5DKFZP434B205, Fbw5, MGC20962
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Proteintech Group | 18321-1-AP | 1 references | Polyclonal |
WB
EL
IHC
|
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Invitrogen Antibodies | PA5-98723 | Polyclonal |
WB
EL
ICC
IHC |
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Cusabio Biotech Co., Ltd | CSB-PA846577LA01HU | Polyclonal |
WB
EL
ICC
IHC |
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LSBio | LS-C677913 | Polyclonal |
WB
EL
ICC
IHC |
||
NovoPro Bioscience Inc. | 110565 | Polyclonal |
WB
EL
IHC
|
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