Tissue expression
Cell line expression
Protein structure
OTOP1
Otopetrin 1This gene encodes a transmembrane protein which belongs to the otopetrin domain protein family and is required for the formation of otoconia and otoliths, calcium carbonate biominerals within the inner ear of mammals that are required for the detection of linear acceleration and gravity. This gene modulates purinergic control of intracellular calcium in vestibular supporting cells. Naturally occurring mutations in the orthologous mouse gene are associated with nonsyndromic otoconia agenesis and a consequent balance defect. The orthologous mouse gene is also induced in white adipose tissue during obesity. The encoded protein is a component of a counterinflammatory pathway that attenuates obesity-induced adipose tissue inflammation and plays an adaptive role in maintaining metabolic homeostasis in obesity. [provided by RefSeq, Jul 2017]
Top validated antibodies |
|||||
antibodies-online | ABIN953949 | 1 references | Polyclonal |
WB
IHC |
|
Cusabio Biotech Co., Ltd | CSB-PA752530LA01HU | Polyclonal |
EL
ICC
IHC
|
||
Biorbyt | orb185690 | Polyclonal |
EL
ICC
IHC
|
||
Invitrogen Antibodies | AHC-005-200UL | Polyclonal |
WB
IHC |
||
OriGene | AP53128PU-N | Polyclonal |
WB
IHC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider