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Protein structure
PITX2
Paired like homeodomain 2ARP1, Brx1, IGDS, IHG2, IRID2, Otlx2, RGS, RIEG, RIEG1, RS
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Invitrogen Antibodies |  PA5-98817 |
1 references | Polyclonal |
WB
EL
ICC
IHC
OA
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| Novus Biologicals | H00005308-M01 |
4 references | Monoclonal |
WB
EL
ICC
ChIP
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| antibodies-online | ABIN562251 |
2 references | Monoclonal |
WB
EL
ICC
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| Abnova Corporation | H00005308-M01 |
2 references | Monoclonal |
EL
ICC
|
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| Cusabio Biotech Co., Ltd | CSB-PA860349LA01HU |
Polyclonal |
WB
EL
ICC
IHC
|
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