Tissue expression
Cell line expression
Protein structure
PTTG1
PTTG1 regulator of sister chromatid separation, securinEAP1, HPTTG, PTTG, securin, TUTR1
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Top validated antibodies |
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Invitrogen Antibodies | PA5-29399 | 1 references | Polyclonal |
WB
ICC
IP
IHC
OA
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Novus Biologicals | NBP2-75659 | Monoclonal |
WB
ICC
IP
IHC
FC
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antibodies-online | ABIN787318 | Polyclonal |
WB
ICC
IP
IHC |
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GeneTex | GTX111938 | Polyclonal |
WB
ICC
IP
IHC |
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HUABIO Research | ET7107-50 | Monoclonal |
WB
ICC
IP
IHC
FC
|
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Supportive data in Antibodypedia
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Recommended by provider