UNCX

This gene encodes a homeobox transcription factor that is involved in somitogenesis and neurogenesis and is required for the maintenance and differentiation of specific elements of the axial skeleton. This gene also plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and deliver hormones that control peripheral functions. The expression of this gene is associated with an increased frequency of acute myeloid leukemia. [provided by RefSeq, Jul 2017]

Description

UNC homeobox

Tissue specificity

Tissue enriched (brain)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

7 (1232872 - 1237326)

Ensembl ID

ENSG00000164853  (ver. 103.38)

Orthologs

Mouse Uncx: ENSMUSG00000029546

UniProt

A6NJT0

neXtProt

NX_A6NJT0

Human splice variants
Mouse splice variants

Protein structure