AQP3

This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Description

Aquaporin 3 (Gill blood group)

Tissue specificity

Tissue enhanced (esophagus, urinary bladder)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

Blood group antigen proteins
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (33441156 - 33447596)

Ensembl ID

ENSG00000165272  (ver. 103.38)

Orthologs

Mouse Aqp3: ENSMUSG00000028435

UniProt

Q92482

neXtProt

NX_Q92482

Human splice variants
Mouse splice variants

Protein structure