Tissue expression
Cell line expression
Protein structure
FBXO22
F-box protein 22FBX22, FISTC1
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Top validated antibodies |
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Proteintech Group | 13606-1-AP | 24 references | Polyclonal |
WB
EL
IP
IHC |
|
antibodies-online | ABIN393870 | 5 references | Monoclonal |
WB
EL
IHC
|
|
Invitrogen Antibodies | 13606-1-AP | Polyclonal |
WB
IP
IHC
OA |
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NovoPro Bioscience Inc. | 110550 | Polyclonal |
WB
EL
IP
IHC |
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GeneTex | GTX117774 | 1 references | Polyclonal |
WB
IHC |
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